Serum levels of C-terminal agrin fragment (CAF) are associated with sarcopenia in older multimorbid community-dwellers: Results from the ilSIRENTE study.
Identifieur interne : 000017 ( Main/Exploration ); précédent : 000016; suivant : 000018Serum levels of C-terminal agrin fragment (CAF) are associated with sarcopenia in older multimorbid community-dwellers: Results from the ilSIRENTE study.
Auteurs : Francesco Landi [Italie] ; Riccardo Calvani [Italie] ; Maria Lorenzi [Italie] ; Anna Maria Martone [Italie] ; Matteo Tosato [Italie] ; Michael Drey [Allemagne] ; Emanuela D'Angelo [Italie] ; Ettore Capoluongo [Italie] ; Andrea Russo [Italie] ; Roberto Bernabei [Italie] ; Graziano Onder [Italie] ; Emanuele Marzetti [Italie]Source :
- Experimental gerontology ; 2016.
Abstract
The C-terminal agrin fragment (CAF), a circulating byproduct of neuromuscular junction disassembly, has been proposed as a possible biomarker for sarcopenia. However, its validity in "real-world", multimorbid older persons is currently unknown. The present study was undertaken to verify if serum CAF levels were associated with sarcopenia in a population of old and very old persons living in the community.
DOI: 10.1016/j.exger.2016.03.012
PubMed: 27015736
Affiliations:
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L'Aquila, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Teaching Nursing Home "Opera Santa Maria della Pace", Fontecchio-Celano, L'Aquila</wicri:regionArea><wicri:noRegion>L'Aquila</wicri:noRegion></affiliation></author><author><name sortKey="Bernabei, Roberto" sort="Bernabei, Roberto" uniqKey="Bernabei R" first="Roberto" last="Bernabei">Roberto Bernabei</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Onder, Graziano" sort="Onder, Graziano" uniqKey="Onder G" first="Graziano" last="Onder">Graziano 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Electronic address: francesco.landi@rm.unicatt.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Calvani, Riccardo" sort="Calvani, Riccardo" uniqKey="Calvani R" first="Riccardo" last="Calvani">Riccardo Calvani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Lorenzi, Maria" sort="Lorenzi, Maria" uniqKey="Lorenzi M" first="Maria" last="Lorenzi">Maria Lorenzi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Martone, Anna Maria" sort="Martone, Anna Maria" uniqKey="Martone A" first="Anna Maria" last="Martone">Anna Maria Martone</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Tosato, Matteo" sort="Tosato, Matteo" uniqKey="Tosato M" first="Matteo" last="Tosato">Matteo Tosato</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Drey, Michael" sort="Drey, Michael" uniqKey="Drey M" first="Michael" last="Drey">Michael Drey</name><affiliation wicri:level="3"><nlm:affiliation>Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universitat Munchen, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik und Poliklinik IV, Schwerpunkt Akutgeriatrie, Klinikum der Universitat Munchen, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="D Angelo, Emanuela" sort="D Angelo, Emanuela" uniqKey="D Angelo E" first="Emanuela" last="D'Angelo">Emanuela D'Angelo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Capoluongo, Ettore" sort="Capoluongo, Ettore" uniqKey="Capoluongo E" first="Ettore" last="Capoluongo">Ettore Capoluongo</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Russo, Andrea" sort="Russo, Andrea" uniqKey="Russo A" first="Andrea" last="Russo">Andrea Russo</name><affiliation wicri:level="1"><nlm:affiliation>Teaching Nursing Home "Opera Santa Maria della Pace", Fontecchio-Celano, L'Aquila, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Teaching Nursing Home "Opera Santa Maria della Pace", Fontecchio-Celano, L'Aquila</wicri:regionArea><wicri:noRegion>L'Aquila</wicri:noRegion></affiliation></author><author><name sortKey="Bernabei, Roberto" sort="Bernabei, Roberto" uniqKey="Bernabei R" first="Roberto" last="Bernabei">Roberto Bernabei</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Onder, Graziano" sort="Onder, Graziano" uniqKey="Onder G" first="Graziano" last="Onder">Graziano Onder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Marzetti, Emanuele" sort="Marzetti, Emanuele" uniqKey="Marzetti E" first="Emanuele" last="Marzetti">Emanuele Marzetti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: emarzetti@live.com.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><series><title level="j">Experimental gerontology</title><idno type="e-ISSN">1873-6815</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The C-terminal agrin fragment (CAF), a circulating byproduct of neuromuscular junction disassembly, has been proposed as a possible biomarker for sarcopenia. However, its validity in "real-world", multimorbid older persons is currently unknown. The present study was undertaken to verify if serum CAF levels were associated with sarcopenia in a population of old and very old persons living in the community.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Italie</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Latium</li></region><settlement><li>Munich</li><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Landi, Francesco" sort="Landi, Francesco" uniqKey="Landi F" first="Francesco" last="Landi">Francesco Landi</name></region><name sortKey="Bernabei, Roberto" sort="Bernabei, Roberto" uniqKey="Bernabei R" first="Roberto" last="Bernabei">Roberto Bernabei</name><name sortKey="Calvani, Riccardo" sort="Calvani, Riccardo" uniqKey="Calvani R" first="Riccardo" last="Calvani">Riccardo Calvani</name><name sortKey="Capoluongo, Ettore" sort="Capoluongo, Ettore" uniqKey="Capoluongo E" first="Ettore" last="Capoluongo">Ettore Capoluongo</name><name sortKey="D Angelo, Emanuela" sort="D Angelo, Emanuela" uniqKey="D Angelo E" first="Emanuela" last="D'Angelo">Emanuela D'Angelo</name><name sortKey="Lorenzi, Maria" sort="Lorenzi, Maria" uniqKey="Lorenzi M" first="Maria" last="Lorenzi">Maria Lorenzi</name><name sortKey="Martone, Anna Maria" sort="Martone, Anna Maria" uniqKey="Martone A" first="Anna Maria" last="Martone">Anna Maria Martone</name><name sortKey="Marzetti, Emanuele" sort="Marzetti, Emanuele" uniqKey="Marzetti E" first="Emanuele" last="Marzetti">Emanuele Marzetti</name><name sortKey="Onder, Graziano" sort="Onder, Graziano" uniqKey="Onder G" first="Graziano" last="Onder">Graziano Onder</name><name sortKey="Russo, Andrea" sort="Russo, Andrea" uniqKey="Russo A" first="Andrea" last="Russo">Andrea Russo</name><name sortKey="Tosato, Matteo" sort="Tosato, Matteo" uniqKey="Tosato M" first="Matteo" last="Tosato">Matteo Tosato</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Drey, Michael" sort="Drey, Michael" uniqKey="Drey M" first="Michael" last="Drey">Michael Drey</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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